A client receiving prednisone should avoid which medication?

Clients receiving prednisone, a corticosteroid, should avoid nonsteroidal anti-inflammatory drugs (NSAIDs) such as naproxen. The use of NSAIDs in conjunction with prednisone increases the risk of gastrointestinal side effects, particularly the risk of ulceration and gastrointestinal bleeding. Corticosteroids can irritate the stomach lining and, when combined with NSAIDs, this irritation can be exacerbated, leading to a higher chance of severe gastrointestinal complications.

In contrast, medications like valsartan, omeprazole, and acetaminophen do not carry the same level of risk for gastrointestinal issues when used with prednisone. Omeprazole, for example, is a proton pump inhibitor that might actually be prescribed to protect the stomach lining in patients taking corticosteroids. Acetaminophen is often a safer pain management option that does not have the same gastrointestinal risks as NSAIDs. Valsartan, an antihypertensive, does not interact significantly with prednisone in a way that would pose a notable risk. Therefore, avoiding naproxen while on prednisone is a crucial recommendation for client safety.