Many infants with an atrioventricular canal also have a diagnosis of which of the following?

Infants diagnosed with an atrioventricular canal (AV canal) often have Congenital Heart Defects associated with genetic syndromes, the most common of which is Trisomy 21, also known as Down syndrome. This condition is characterized by an extra copy of chromosome 21 and is strongly linked to congenital heart defects, particularly those affecting the structure and connections of the heart like the AV canal.

In the case of AV canal defects, they involve a combination of atrial septal defects and ventricular septal defects with a single common atrioventricular valve. This structural abnormality is frequently seen in children with Trisomy 21, leading to increased clinical attention for early diagnosis and management.

Other syndromes like Trisomy 18, Turner syndrome, and DiGeorge syndrome can also be associated with certain congenital defects, but the prevalence and specific correlation to atrioventricular canal defects are less significant compared to Trisomy 21. Hence, Trisomy 21 stands out as the most relevant genetic condition in relation to AV canal abnormalities.